I don't want to give any of the story away (which makes reviewing it kind of tricky!), but safe to say it's touching, disturbing, riveting, intelligent, laugh-out-loud funny and compulsive reading. The quality of the story is even matched by the book itself - It's beautifully designed, and I don't think I've ever seen such luxurious, thick paper stock used in a book like this before.
If you've enjoyed Clowes classics such as David Boring and Ghost World, then you are in for a treat with this. If you've never read any of his titles before, then Wilson is the perfect introduction to his world.